"I am deeply saddened by the loss of life and devastation caused by the earthquake in Turkey and Syria. I have directed my team to continue to closely monitor the situation in coordination with Turkey and provide any and all needed assistance," the president tweeted from his official account.
"Our teams are deploying quickly to begin to support Turkish search and rescue efforts and address the needs of those injured and displaced by the earthquake," he added in a statement later released by the White House.
The magnitude 7.8 quake, which hit before sunrise in bitter winter weather, was the worst to strike Turkey this century. It was followed in the early afternoon by another large quake of magnitude 7.7.
Turkish government officials said at least 1,651 people had died in the 7.8-magnitude tremor, with another 968 confirmed fatalities in neighboring Syria, putting the total at 2,619.
It was not immediately clear how much damage had been done by the second quake, which like the first was felt across the region and endangered rescuers struggling to pull casualties from the rubble.
The White House statement said Biden had called on US officials to reach out to their Turkish counterparts to coordinate on assistance, and that humanitarian groups supported by the United States were responding to the destruction in Syria.
"Today, our hearts and our deepest condolences are with all those who have lost precious loved ones, those who are injured, and those who saw their homes and businesses destroyed," he said in the statement.