Washington is seeking information on Mohamoud Abdi Aden, describing him as a leader of the Somalia-based Al-Shabab jihadist group that has carried out several deadly attacks in neighboring Kenya.
The Al-Qaeda affiliated group claimed responsibility for the January 15, 2019 siege on the upmarket DusitD2 hotel compound in the Kenyan capital Nairobi that lasted almost 20 hours.
At least 21 people lost their lives, including a US citizen, and many more were injured. Kenya said at the time that all the assailants had been eliminated.
"Mohamoud Abdi Aden, an Al-Shabab leader, was part of the cell that the planned the DusitD2 hotel attack," the US ambassador to Kenya, Meg Whitman, told reporters in Nairobi.
She said the US was offering a reward of up to $10 million for information leading to the arrest of Aden, described by the embassy as a Kenyan national, and others accused of involvement in the hotel siege.
The head of Kenya's Directorate of Criminal Investigations, Amin Mohamed Ibrahim, described Aden as the "terror mastermind" behind the carnage.
The State Department designated Aden a "specially designated global terrorist" in October last year.
Al-Shabab has repeatedly targeted Kenya since it sent its army into Somalia in October 2011 to fight the Islamist militant group.
In 2013, Al-Shabaab laid siege to the Westgate shopping mall in Nairobi for four days, leaving 67 people dead.
In 2015, an attack on Garissa University in eastern Kenya killed 148 people, almost all of them students. Many were shot at point blank range after being identified as Christians.
It was the second bloodiest attack in Kenya's history, surpassed only by Al-Qaeda's bombing of the US embassy in Nairobi in 1998 that killed 213 people.
Al-Shabab, which has been waging a bloody insurgency against Somalia's fragile central government for 15 years, has been designated a terrorist group by the US since 2008.
In November, Washington said it was increasing its reward to up to $10 million apiece for key Al-Shabab leaders including "emir" Ahmed Diriye.